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Hi Peter, It was easy to titrate down as the opiates made me very nauseous and dizzy on the tirzepatide. I literally halved the dose of the oxycontin every day (as full dose made me feel awful). The physical withdrawals I experienced once I stopped altogether lasted only a couple of days and consisted of some mild nights sweats, restless legs and leg cramps, insomnia and a bit of anxiety but I experienced no cravings as such. I did take 15mgs of codeine twice, 48 hrs apart to ease the cramps in that week. Sherry

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Thanks for this great and crucial work that you’re doing. It’s desperately needed. Another point of pressure on govts could be through domestic violence prevention. The federal govt here is throwing buckets of money at DV prevention which is mainly useless awareness campaigns saying the obvious, or to divide the sexes further into victims/abusers, when the evidence overwhelmingly indicates alcohol as being a cause of most low level isolated incidents.

Do you also think Mounjaro is more effective? I’ve only been on Wegovy for a week, and while I’ve only drank one night, I could have easily drank more and more often. No immediate obliteration for me yet, and feel quite lethargic and flat, tbh. Definitely don’t want to eat though, but I’d have beer instead of dinner now, rather than with food! Gone off wine though, which is definitely something.

And one other small thing that bugs me - this woman is Australian- I’m in Australia- and we do not ever use pounds and inches. It’s always annoying to have to convert these old imperial measurements to metric, otherwise it’s meaningless, but I get that it’s American and that’s what you use, but given you’ve kept all Aus terms in, can you please just leave it in metric or include both terms, so the rest of the world understands that she’s 135kg and 160cm? Sorry, and thank you!

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Hi Michelle-- that's a great point about domestic violence. ~60% of crime is related to drug or alcohol abuse and I agree that this would have tremendous downstream benefits. The alcohol prohibition movement here in the United States was a women's movement driven largely by concerns about men abusing women while drunk.

Mounjaro may be more effective, it is for food, but it's unknown for other things. And if you are already seeing a reduction in drinking at your initial dose level, that reduction is very likely to grow (shrink?) as you move up to the next dose level.

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That's great but there is no real discussion of the withdrawal issues. Is she claiming she could just go cold turkey or that it was easy to titrate down once she no longer had the craving?

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