7 Comments

Now, this is really becoming exciting in a very giddy way. I'm a clinical psychologist and I sometimes work with SUDs patients. I therefore appreciate the potential value of this creeping pharmacological revolution in addiction management. But the sceptic in me is also screaming for cases in which GLP-1S was a failure. There're bound to be such cases, right? And we need to understand why they didn't work. Thanks for what you do on this newsletter .

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They don’t work for everyone, though for alcohol it seems like nearly everyone sees some reduction, based on patient reports. If you look around on Reddit you’ll see a few stories of less or no reductions in drug use.

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Do we have any idea or hypothesis about these no- or low-response cases? Are there contraindications that we need to be aware of?

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I have a friend who hasn't had any effects from Mounjaro, not weight loss or decline in drinking. She has gastroparesis, and I wonder if this has anything to do with why it's not working for her. Maybe it's the medication she takes for it, Domperidone?

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It doesn't work for my friend who has gastroparesis and takes Domperidone. (Duplicate post, wanted to reply to you specifically)

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Do they take an oral GLP-1 or an injection?

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Melissa, I'm so happy for you. I've had the same experience. Like you, for the first time in my life I feel like I could have a couple of drinks without going overboard. I would never ever try it because I put my family through too much, not to mention the long-term effects it's had on me.

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