3 Comments
Oct 18Liked by Nicholas Reville

Now, this is really becoming exciting in a very giddy way. I'm a clinical psychologist and I sometimes work with SUDs patients. I therefore appreciate the potential value of this creeping pharmacological revolution in addiction management. But the sceptic in me is also screaming for cases in which GLP-1S was a failure. There're bound to be such cases, right? And we need to understand why they didn't work. Thanks for what you do on this newsletter .

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They don’t work for everyone, though for alcohol it seems like nearly everyone sees some reduction, based on patient reports. If you look around on Reddit you’ll see a few stories of less or no reductions in drug use.

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Do we have any idea or hypothesis about these no- or low-response cases? Are there contraindications that we need to be aware of?

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