Announcing a major 1,200 person trial of a GLP-1 for addiction recovery and recidivism

New RCT enrolling Q1 2027 from CASPR and Allegheny County, with researchers from MIT, UCSD, Pitt, and UPMC.

Oct 13 • Nicholas Reville

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PBS Newshour coverage of CASPR’s GLP-1 for addiction pilot programs

Two years ago, I reached out to the Director of Research at Caron Treatment Centers after seeing the results of the Phase 1/2 trial they had run with…

Oct 11 • Nicholas Reville

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June 2026

Making a non-opioid painkiller available to everyone would save Medicare and Medicaid $14.9B and prevent hundreds of thousands of new…

Suzetrigine is sitting on the shelf waiting for its patent to expire, while hundreds of thousands of new opioid addictions are being caused by…

Jun 18 • Nicholas Reville

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Addiction is like an iceberg: most of the harms are below the surface

A visualization of the direct and downstream effects of addiction.

Jun 4 • Nicholas Reville

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May 2026

How can government drive more medication development for addiction? Our work in DC.

CASPR gets FDA acceleration language for SUD into the House Appropriations Committee report.

May 22 • Nicholas Reville

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The FDA and a breakthrough for drug repurposing efforts

Finding a path for off-patent drugs to reach patients for new uses

May 14 • Eli Spector and Nicholas Reville

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New semaglutide for alcohol use disorder trial shows big drops in drinking

Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial…

May 1 • Nicholas Reville

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March 2026

CASPR is hiring

Director of Research, Director of Policy, and Policy Lead

Mar 16 • Eli Spector, Nicholas Reville, and Lindsay Holden

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First ever 50-state ranking of online gambling safety

See your state's report card and ranking, from Montana at #1 to Delaware at #50.

Mar 4 • Nicholas Reville

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2026 is the year DraftKings will face serious opposition for the first time

Online gambling is the new tobacco: the public is realizing they've been scammed.

Mar 4 • Nicholas Reville

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February 2026

By making suzetrigine cheap, we could cut opioid prescriptions in half

A win / win / win deal for the public, the government, and the drugmaker can cut the Gordian knot of pain prescription tradeoffs.

Feb 10 • Nicholas Reville

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NIH High Leverage Trials (HILT) Proposal

Large-scale Research for Repurposing and Supplements

Feb 3 • Nicholas Reville

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